3,3'-Diindolylmethane
3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
Product Specifications
CAS Number
1968-05-4
Product Name Alternative
DIM; Arundine; HB 236
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
Androgen Receptor; Autophagy
Type
Natural Products
Related Pathways
Autophagy; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3,3_acute_-Diindolylmethane.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4
Molecular Formula
C17H14N2
Molecular Weight
246.31
Precautions
H315, H319, H335, H413
References & Citations
[1]Le HT, et al. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003 Jun 6;278 (23) :21136-45.|[2]Li XJ, et al. 3,3'-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway. Oncol Rep. 2013 Nov;30 (5) :2419-26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Phase 4
Available Sizes
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