3,3'-Diindolylmethane

3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

Product Specifications

CAS Number

[1968-05-4]

Product Name Alternative

DIM; Arundine; HB 236

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H413

Target

Androgen Receptor; Autophagy

Type

Natural Products

Related Pathways

Autophagy; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3,3_acute_-Diindolylmethane.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C1(CC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4

Molecular Formula

C17H14N2

Molecular Weight

246.31

Precautions

H315, H319, H335, H413

References & Citations

[1]Le HT, et al. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003 Jun 6;278 (23) :21136-45.|[2]Li XJ, et al. 3,3'-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway. Oncol Rep. 2013 Nov;30 (5) :2419-26.