ICOS Antibody (C-term) [APR05699G]
Product Specifications
Background
Tissue Location: Activated T-cells. Highly expressed on tonsillar T- cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus
Synonyms
Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Gene Name
ICOS
Gene ID
29851
UniProt
Q9Y6W8
Chromosomal Location
[Isoform 1]: Cell membrane; Single- pass type I membrane protein
Applications
IHC-P, WB, FC
Dilution
IHC-P--1:100~500 WB--1:1000 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching of immunoglobin isotypes (By similarity) .
Molecular Weight
22625
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ICOS Antibody (C-term) [APR05699G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=29851
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y6W8
Available Sizes
Curated Selection
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