PYHIN1 Antibody (N-term) [APR05643G]
Product Specifications
Background
Tissue Location: Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PYHIN1 Antibody (N-term) [APR05643G].
Synonyms
Pyrin and HIN domain-containing protein 1, Interferon-inducible protein X, PYHIN1, IFIX
Gene Name
PYHIN1
Gene ID
149628
UniProt
Q6K0P9
Chromosomal Location
[Isoform 1]: Nucleus, nucleoplasm. [Isoform 5]: Nucleus. Nucleus speckle.
Applications
WB, IHC-P, FC
Dilution
WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Molecular Weight
55065
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=149628
Uniprot URL
https://www.uniprot.org/uniprot/Q6K0P9
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