STAM Antibody (C-term) [APR04929G]
Product Specifications
Background
Tissue Location: Ubiquitously expressed.
Synonyms
Signal transducing adapter molecule 1, STAM-1, STAM, STAM1
Gene Name
STAM
Gene ID
8027
UniProt
Q92783
Chromosomal Location
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side
Applications
WB, IHC-P
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex) . The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Molecular Weight
59180
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAM Antibody (C-term) [APR04929G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8027
Uniprot URL
https://www.uniprot.org/uniprot/Q92783
Available Sizes
Curated Selection
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