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Mouse Myocd Antibody (C-term) [APR04747G]

Product Specifications

Background

Tissue Location: Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues Isoform 3 is the most abundant isoform in the heart from embryo to adult.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Myocd Antibody (C-term) [APR04747G].

Synonyms

Myocardin, Basic SAP coiled-coil transcription activator 2, SRF cofactor protein, Myocd, Bsac2, Mycd, Srfcp

Gene Name

Myocd

Gene ID

214384

UniProt

Q8VIM5

Chromosomal Location

Nucleus speckle. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei

Applications

WB

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) . Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.

Molecular Weight

101400

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/?term=214384

Uniprot URL

https://www.uniprot.org/uniprot/Q8VIM5

Available Sizes

Frequently Asked Questions

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