Bixin

Bixin is an orally active carotenoid found in the seeds of Bixa orellana. Bixin induces apoptosis in cancer cells. Bixin possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation[1][2].

Product Specifications

CAS Number

[6983-79-5]

UNSPSC

12352211

Hazard Statement

H302, H315, H319

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bixin.html

Purity

99.53

Solubility

DMSO : 7.14 mg/mL (ultrasonic)

Smiles

OC(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)\C=C\C(OC)=O)=O

Molecular Formula

C25H30O4

Molecular Weight

394.50

Precautions

H302, H315, H319

References & Citations

[1]Xu Z, et al. Bixin ameliorates high fat diet-induced cardiac injury in mice through inflammation and oxidative stress suppression. Biomed Pharmacother. 2017 May;89:991-1004.|[2]Kusmita L, et al. Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro. Nat Prod Res. 2022 Dec;36 (24) :6421-6427.