IL17RE Antibody (N-term) [APR04458G]

Product Specifications

Background

Tissue Location: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL17RE Antibody (N-term) [APR04458G].

Synonyms

Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE

Gene Name

IL17RE

Gene ID

132014

UniProt

Q8NFR9

Chromosomal Location

[Isoform 1]: Cell membrane; Single- pass type I membrane protein [Isoform 3]: Secreted. [Isoform 5]: Secreted.

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.