Mouse Shb Antibody (C-term) [APR04408G]
Product Specifications
Background
Tissue Location: Expressed in heart, liver, brain and kidney (at protein level) .
Synonyms
SH2 domain-containing adapter protein B, Shb
Gene Name
Shb
Gene ID
230126
UniProt
Q6PD21
Chromosomal Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin- producing cells (By similarity) .
Molecular Weight
54708
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Shb Antibody (C-term) [APR04408G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=230126
Uniprot URL
https://www.uniprot.org/uniprot/Q6PD21
Available Sizes
Curated Selection
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