TIGAR Antibody (N-term) [APR04405G]

Product Specifications

Background

Tissue Location: Expressed in the brain (PubMed:22887998) . Expressed in breast tumors (PubMed:21820150) . Expressed in glioblastomas (PubMed:22887998) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TIGAR Antibody (N-term) [APR04405G].

Synonyms

Fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5

Gene Name

TIGAR {ECO:0000303|PubMed:16839880}

Gene ID

57103

UniProt

Q9NQ88

Chromosomal Location

Cytoplasm. Nucleus Mitochondrion. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017) . Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017) . Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429) . Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD) /reoxygenation insult in primary neurons (By similarity) . {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.