Bmp10 Antibody (N-term) [APR04175G]
Product Specifications
Background
Tissue Location: Detected in mammary epithelia (at protein level) .
Synonyms
Bone morphogenetic protein 10, BMP-10, BMP10
Gene Name
BMP10
Gene ID
27302
UniProt
O95393
Chromosomal Location
Secreted.
Applications
WB, IHC-P
Dilution
WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Molecular Weight
48047
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bmp10 Antibody (N-term) [APR04175G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=27302
Uniprot URL
https://www.uniprot.org/uniprot/O95393
Available Sizes
Curated Selection
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