KLHL25 Antibody (N-term) [APR04105G]
Product Specifications
Synonyms
Kelch-like protein 25, Ectoderm-neural cortex protein 2, ENC-2, KLHL25, ENC2
Gene Name
KLHL25
Gene ID
64410
UniProt
Q9H0H3
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR (KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1) : ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR (KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Molecular Weight
65923
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KLHL25 Antibody (N-term) [APR04105G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=64410
Uniprot URL
https://www.uniprot.org/uniprot/Q9H0H3
Available Sizes
Curated Selection
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