SIGLEC11 Antibody (N-term) [APR04093G]

Product Specifications

Background

Tissue Location: Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIGLEC11 Antibody (N-term) [APR04093G].

Synonyms

Sialic acid-binding Ig-like lectin 11, Sialic acid-binding lectin 11, Siglec-11, SIGLEC11

Gene Name

SIGLEC11

Gene ID

114132

UniProt

Q96RL6

Chromosomal Location

Membrane; Single-pass type I membrane protein.

Applications

IHC-P, WB

Dilution

WB--1:500 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.