Mouse Dyrk1b Antibody (Center) [APR03984G]
Product Specifications
Background
Tissue Location: Isoform 1 and isoform 2 are broadly expressed. Isoform 3 seems specific for skeletal muscle (at protein level)
Synonyms
Dual specificity tyrosine-phosphorylation-regulated kinase 1B, Dyrk1b
Gene Name
Dyrk1b
Gene ID
13549
UniProt
Q9Z188
Chromosomal Location
Nucleus.
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1) .
Molecular Weight
69178
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Dyrk1b Antibody (Center) [APR03984G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=13549
Uniprot URL
https://www.uniprot.org/uniprot/Q9Z188
Available Sizes
Curated Selection
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