STAM2 Antibody (Center) [APR03900G]

Product Specifications

Background

Tissue Location: Ubiquitously expressed.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAM2 Antibody (Center) [APR03900G].

Synonyms

Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP

Gene Name

STAM2

Gene ID

10254

UniProt

O75886

Chromosomal Location

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex) . The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity) .