REC8 Antibody (Center) [APR03837G]
Product Specifications
Background
Tissue Location: Expressed in testis and thymus. Expressed in the B- cell lines WI-L2-NS and Namalwa (at protein level)
Synonyms
Meiotic recombination protein REC8 homolog, Cohesin Rec8p, REC8, REC8L1
Gene Name
REC8
Gene ID
9985
UniProt
O95072
Chromosomal Location
Nucleus {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome, centromere {ECO:0000250|UniProtKB:Q6AYJ4}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localised to centromeres and spindle poles in endopolyploid tumor cells {ECO:0000250|UniProtKB:Q6AYJ4}
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity) .
Molecular Weight
62614
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality REC8 Antibody (Center) [APR03837G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=9985
Uniprot URL
https://www.uniprot.org/uniprot/O95072
Available Sizes
Curated Selection
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