Bak Antibody (BH3 Domain Specific) [APR03765G]
Product Specifications
Background
Tissue Location: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle
Synonyms
Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7, BAK1, BAK, BCL2L7, CDN1
Gene Name
BAK1
Gene ID
578
UniProt
Q16611
Chromosomal Location
Mitochondrion outer membrane; Single-pass membrane protein
Applications
IHC-P, WB
Dilution
WB--1:2000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Molecular Weight
23409
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bak Antibody (BH3 Domain Specific) [APR03765G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=578
Uniprot URL
https://www.uniprot.org/uniprot/Q16611
Available Sizes
Curated Selection
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