Bak Antibody (BH3 Domain Specific) [APR03765G]

Product Specifications

Background

Tissue Location: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bak Antibody (BH3 Domain Specific) [APR03765G].

Synonyms

Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7, BAK1, BAK, BCL2L7, CDN1

Gene Name

BAK1

Gene ID

578

UniProt

Q16611

Chromosomal Location

Mitochondrion outer membrane; Single-pass membrane protein

Applications

IHC-P, WB

Dilution

WB--1:2000 IHC-P--1:100~500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.