SAMD8 Antibody (N-term) [APR03647G]
Product Specifications
Synonyms
Sphingomyelin synthase-related protein 1, SMSr, 278-, Ceramide phosphoethanolamine synthase, CPE synthase, Sterile alpha motif domain-containing protein 8, SAM domain-containing protein 8, SAMD8
Gene Name
HGNC:26320
Gene ID
142891
UniProt
Q96LT4
Chromosomal Location
Endoplasmic reticulum membrane; Multi-pass membrane protein
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
Molecular Weight
48321
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SAMD8 Antibody (N-term) [APR03647G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=142891
Uniprot URL
https://www.uniprot.org/uniprot/Q96LT4
Available Sizes
Curated Selection
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