LOC129293 Antibody (C-term) [APR03610G]

Product Specifications

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LOC129293 Antibody (C-term) [APR03610G].

Synonyms

Metalloprotease TIKI1, 34--, TRAB domain-containing protein 2A, TRABD2A, C2orf89, TIKI1

Gene Name

TRABD2A

Gene ID

129293

UniProt

Q86V40

Chromosomal Location

Cell membrane; Single-pass type I membrane protein

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.