MITF Antibody (N-term) [APR03575G]
Product Specifications
Background
Tissue Location: Expressed in melanocytes (at protein level) . [Isoform C2]: Expressed in the kidney and retinal pigment epithelium. [Isoform H2]: Expressed in the kidney. [Isoform Mdel]: Expressed in melanocytes.
Synonyms
Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32, MITF, BHLHE32
Gene Name
MITF
Gene ID
4286
UniProt
O75030
Chromosomal Location
Nucleus. Cytoplasm Note=Found exclusively in the nucleus upon phosphorylation
Applications
WB, IF, FC
Dilution
WB--1:2000 WB--1:1000 IF--1:10~50 FC--1:10~50 IHC--1:800
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) . Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) . Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Molecular Weight
58795
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MITF Antibody (N-term) [APR03575G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4286
Uniprot URL
https://www.uniprot.org/uniprot/O75030
Available Sizes
Curated Selection
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