(E) -5- (2-Bromovinyl) pyrimidine-2,4 (1H,3H) -dione

(E) -5- (2-Bromovinyl) uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E) -5- (2-bromovinyl) -2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

Product Specifications

CAS Number

[69304-49-0]

Product Name Alternative

(E) -5- (2-Bromovinyl) uracil; BVU

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/e-5-2-bromovinyl-pyrimidine-2-4-1h-3h-dione.html

Smiles

O=C1NC(C(/C=C/Br)=CN1)=O

Molecular Formula

C6H5BrN2O2

Molecular Weight

217.02

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]De Clercq, et al. Synthesis and antiviral activity of (E) -5- (2-bromovinyl) uracil and (E) -5- (2-bromovinyl) uridine. J. Med. Chem. 29 (2), 213-217 (1986) .