Vps34-PIK-III
Product Specifications
UNSPSC Description
Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs)[1][2][3].
Target Antigen
Autophagy; PI3K
Type
Reference compound
Related Pathways
Autophagy;PI3K/Akt/mTOR
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Vps34-PIK-III.html
Purity
99.63
Solubility
DMSO : ≥ 31 mg/mL
Smiles
NC1=NC=C(C2=CC=NC(NC3=CC=NC=C3)=N2)C(CC4CC4)=N1
Molecular Weight
319.36
References & Citations
[1]Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. |[2]Liu F, et al. PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor. Cell Death Dis. 2020 Jun 8;11(6):427. |[3]Dowdle WE, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014 Nov;16(11):1069-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12794/Vps34-PIK-III-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12794/Vps34-PIK-III-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1383716-40-2
Available Sizes
Curated Selection
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