Vps34-PIK-III

Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM) . Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs) [1][2][3].

Product Specifications

CAS Number

[1383716-40-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Autophagy; PI3K

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Vps34-PIK-III.html

Purity

99.63

Solubility

DMSO : ≥ 31 mg/mL

Smiles

NC1=NC=C(C2=CC=NC(NC3=CC=NC=C3)=N2)C(CC4CC4)=N1

Molecular Formula

C17H17N7

Molecular Weight

319.36

Precautions

H315, H319, H320

References & Citations

[1]Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015 Nov 13;7 (1) :72-6. |[2]Liu F, et al. PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor. Cell Death Dis. 2020 Jun 8;11 (6) :427. |[3]Dowdle WE, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014 Nov;16 (11) :1069-79.