AR Degrader-2
AR Degrader-2 (Compound 2) is a molecular glue that degrades androgen receptor (AR) with a DC50 of 0.3-0.5 μM in cell VCaP.
Product Specifications
CAS Number
3023359-76-1
UNSPSC
12352005
Target
Androgen Receptor; Molecular Glues
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-degrader-2.html
Smiles
CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)C(N4CCN(CC4)C(/C(C#N)=C/C(C)(C)C)=O)=O)C=C2)=O)[C@H]1OC5=CC(Cl)=C(C=C5)C#N
Molecular Formula
C40H49ClN6O4
Molecular Weight
713.31
References & Citations
[1]Testa A, et al., Bifunctional molecules for targeted protein degradation. WO2023242598A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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