MNK1/2-IN-8
MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].
Product Specifications
CAS Number
2430793-35-2
UNSPSC
12352005
Target
MNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mnk1-2-in-8.html
Smiles
O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2
Molecular Formula
C26H24N6O
Molecular Weight
436.51
References & Citations
[1]Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4- (indolin-1-yl) -6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK1; MNK2
Frequently Asked Questions
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