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MNK1/2-IN-8

MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].

Product Specifications

CAS Number

2430793-35-2

UNSPSC

12352005

Target

MNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mnk1-2-in-8.html

Smiles

O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2

Molecular Formula

C26H24N6O

Molecular Weight

436.51

References & Citations

[1]Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4- (indolin-1-yl) -6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MNK1; MNK2

Frequently Asked Questions

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