Isonardosinone
Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of iNOS and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056) -induced BV2 microglia, exhibits anti-inflammatory activity[1].
Product Specifications
CAS Number
[27062-01-7]
UNSPSC
12352005
Target
COX; NF-κB; NO Synthase; p38 MAPK
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isonardosinone.html
Smiles
C[C@@]12[C@@H]([C@@]3([H])[C@@](O3)([H])C(C1=CCC[C@H]2C)=O)C(C)(O)C
Molecular Formula
C15H22O3
Molecular Weight
250.33
References & Citations
[1]Ko W, et al., Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Inflammation. 2018 Aug;41 (4) :1215-1228.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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