Isonardosinone
Product Specifications
UNSPSC Description
Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of iNOS and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056)-induced BV2 microglia, exhibits anti-inflammatory activity[1].
Target Antigen
COX; NF-κB; NO Synthase; p38 MAPK
Type
Natural Products
Related Pathways
Immunology/Inflammation;MAPK/ERK Pathway;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isonardosinone.html
Smiles
C[C@@]12[C@@H]([C@@]3([H])[C@@](O3)([H])C(C1=CCC[C@H]2C)=O)C(C)(O)C
Molecular Weight
250.33
References & Citations
[1]Ko W, et al., Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Inflammation. 2018 Aug;41(4):1215-1228.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N9955/Isonardosinone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N9955/
Clinical Information
No Development Reported
CAS Number
27062-01-7
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