Isonardosinone

Isonardosinone is a nardosinone-type sesquiterpenes, which can be isolated from Valerianaceae. Isonardosinone inhibits NF-κB and MAPK signaling pathway, suppresses expression of iNOS and cyclooxygenase-2 (COX-2) in Lipopolysaccharides (HY-D1056) -induced BV2 microglia, exhibits anti-inflammatory activity[1].

Product Specifications

CAS Number

[27062-01-7]

UNSPSC

12352005

Target

COX; NF-κB; NO Synthase; p38 MAPK

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isonardosinone.html

Smiles

C[C@@]12[C@@H]([C@@]3([H])[C@@](O3)([H])C(C1=CCC[C@H]2C)=O)C(C)(O)C

Molecular Formula

C15H22O3

Molecular Weight

250.33

References & Citations

[1]Ko W, et al., Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Inflammation. 2018 Aug;41 (4) :1215-1228.