[Des-His1, Glu9]-Glucagon amide
[Des-His1, Glu9]-Glucagon amide is a potent and peptide antagonist of the glucagon receptor, with a pA2 of 7.2. [Des-His1, Glu9]-Glucagon amide is potentially useful in the study of the pathogenesis of diabetes[1].
Product Specifications
CAS Number
[110084-95-2]
UNSPSC
12352209
Target
GCGR
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/des-his1-glu9-glucagon-amide.html
Solubility
H2O
Smiles
C([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC(CNC([C@@H](NC([C@H](CO)N)=O)CCC(N)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CCC(O)=O)=O)=O)CO)=O)CCCCN)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)C(C)C)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)CC(N)=O)=O)CCSC)=O)CC(C)C)=O)C=5C=6C(NC5)=CC=CC6
Molecular Formula
C148H221N41O47S
Molecular Weight
3358.65
References & Citations
[1]Unson CG, et, al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov; 10 (6) : 1171-7.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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