S-Methyl-N, N-diethylthiolcarbamate

S-Methyl-N, N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240) . It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N, N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg) . When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation.

Product Specifications

CAS Number

[686-07-7]

Product Name Alternative

DETC-Me; DDTC-Me; Diethyldithiocarbamic acid methyl ester

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-methyl-n-n-diethylthiolcarbamate.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(SC)N(CC)CC

Molecular Formula

C6H13NS2

Molecular Weight

163.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Hart, et al. S-methyl-N, N-diethylthiolcarbamate: A disulfiram metabolite and potent rat liver mitochondrial low Km aldehyde dehydrogenase inhibitor. Alcohol 7 (2), 165-169 (1990) .