Uridine 5'-diphosphate (sodium salt)

Uridine 5'-diphosphate sodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52) and a potent P2Y14 antagonist (pEC50=7.28) . Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].

Product Specifications

CAS Number

[21931-53-3]

UNSPSC

12352005

Hazard Statement

H371

Target

DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/uridine-5-diphosphate-sodium-salt.html

Purity

98.0

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O[C@@H]([C@H]([C@H](N1C(NC(C=C1)=O)=O)O2)O)[C@H]2COP(O)(OP(O)(O)=O)=O.[Na+].[x]

Molecular Formula

C9H14N2O12P2.xNa

Precautions

H371

References & Citations

[1]Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5 (1) :75-89.|[2]Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186 (6) :3701-9.