Nic-15
Nic-15 (compound 4n) is an anti-constrictive agent used to antagonize the hypovascularity of pancreatic tumors. The hypovascularity allows cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop drug resistance. Nic-15 can regulate the PI3K/Akt/mTOR pathway and alleviate ER stress induced by Gemcitabine (HY-17026) . Nic-15 can significantly inhibit the migration and colony formation of MIA PaCa-2 and PANC-1 pancreatic cancer cells. The combination of Nic-15 and Gemcitabine can effectively solve the problem of pancreatic tumor resistance. In an in vivo xenograft model, Nic-15 can significantly enhance the efficacy of Gemcitabine[1].
Product Specifications
CAS Number
[2896739-91-4]
UNSPSC
12352005
Target
Akt; mTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nic-15.html
Smiles
O=C([C@H]1[C@H](C2=CC=CC(F)=C2F)CC(CC/C=C(C)/C)=CC1)C3=C(O)C=CC=C3O
Molecular Formula
C25H26F2O3
Molecular Weight
412.47
References & Citations
[1]Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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