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Fatostatin (hydrobromide)

Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2].

Product Specifications

CAS Number

[298197-04-3]

Product Name Alternative

125B11 (hydrobromide)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fatty Acid Synthase (FASN)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fatostatin-hydrobromide.html

Purity

99.52

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CCCC1=NC=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=C1.[H]Br

Molecular Formula

C18H19BrN2S

Molecular Weight

375.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28;278 (9) :7320-4.|[2]Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28;16 (8) :882-92.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Free Radic Biol Med. 2025 Aug 19:240:170-182.|Adv Sci (Weinh) . 2025 Apr 24:e2407671.|Autophagy. 2021 Jul;17 (7) :1592-1613.|Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Jun 6:159642.|Biol Pharm Bull. 2022 Apr 1;45 (4) :438-445.|Br J Nutr. 2024 Feb 28;131 (4) :553-566.|Cancer Cell. 2024 Sep 26:S1535-6108 (24) 00350-7.|Cancer Lett. 2024 Jun 18:217068.|Cancers (Basel) . 2023 Jun 3;15 (11) :3043.|Cell Biosci. 2023 Oct 3;13 (1) :186.|Cell Death Differ. 2021 Jun;28 (6) :2001-2018.|Cell Death Dis. 2021 May 26;12 (6) :544.|Cell Death Dis. 2024 Jun 12;15 (6) :411.|Cell Death Dis. 2025 May 16;16 (1) :391.|Cell Death Discov. 2022 Oct 28;8 (1) :431.|Cell Metab. 2021 Aug 3;33 (8) :1655-1670.e8.|Cell Mol Biol Lett. 2024 Aug 21;29 (1) :112.|Cell Mol Immunol. 2025 Oct 29.|Cell Mol Life Sci. 2024 Jul 6;81 (1) :289.|Cell Mol Life Sci. 2025 Jul 3;82 (1) :270.|Cell Rep. 2022 Nov 29;41 (9) :111738.|Cell Rep. 2025 Feb 19;44 (3) :115339.|Emerg Microbes Infect. 2025 Dec;14 (1) :2470371.|Eur J Pharmacol. 2025 Sep 15:1003:177890.|Exp Eye Res. 2025 Jan 10:110239.|Int Immunopharmacol. 2024 Jul 18:139:112669.|iScience. 2024 Jun 29;27 (8) :110424.|J Cell Mol Med. 2025 Jul;29 (14) :e70710.|J Clin Invest. 2025 Jul 8:e193134.|J Ethnopharmacol. 2024 Jan 30;319 (Pt 1) :117162.|J Ethnopharmacol. 2026 Feb 28:357:120890.|J Exp Clin Cancer Res. 2019 May 29;38 (1) :228. |J Pathol. 2020 Dec;252 (4) :358-370.|JCI Insight. 2024 Jun 18:e180132.|Mol Carcinog. 2023 Jul;62 (7) :963-974.|Mol Med. 2024 Feb 21;30 (1) :28.|Mol Oncol. 2025 Jun;19 (6) :1668-1686.|Nat Commun. 2025 Feb 1;16 (1) :1241.|Nat Commun. 2025 Feb 25;16 (1) :1774.|NPJ Precis Oncol. 2024 Mar 1;8 (1) :58.|Oncol Lett. 2020 Sep;20 (3) :2855-2869.|Oncol Rep. 2018 Apr;39 (4) :1919-1929.|Res Sq. 2024 Nov 18.|Research Square Preprint. 2022 May.|Tissue Cell. 2025 Sep 9:98:103134.|University of Tubingen. 2025.

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