GCGR Antibody (Center) [AMM04746G]
Product Specifications
Synonyms
Glucagon receptor, GL-R, GCGR
Gene Name
GCGR
Gene ID
2642
UniProt
P47871
Chromosomal Location
Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding
Applications
WB
Dilution
WB--1:2000 WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Molecular Weight
54009
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GCGR Antibody (Center) [AMM04746G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2642
Uniprot URL
https://www.uniprot.org/uniprot/P47871
Available Sizes
Curated Selection
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