DIO2 Antibody (Center) [APR07583G]

Product Specifications

Background

Tissue Location: Isoform 1 is expressed in the lung, trachea, kidney, heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain (PubMed:8755651, PubMed:11165050) . Isoform 2 is expressed in the brain, heart, kidney and trachea (PubMed:11165050)

Synonyms

Type II iodothyronine deiodinase, 5DII, DIOII, Type 2 DI, Type-II 5'-deiodinase, DIO2, ITDI2, TXDI2

Gene Name

DIO2

Gene ID

1734

UniProt

Q92813

Chromosomal Location

Membrane; Single-pass membrane protein

Applications

WB, IHC-P, FC

Dilution

WB--1:500-2000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) . Essential for providing the brain with appropriate levels of T3 during the critical period of development.

Molecular Weight

30552

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DIO2 Antibody (Center) [APR07583G].