SEPT4 Antibody (N-term) [AMR09866G]

Product Specifications

Background

Tissue Location: Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SEPT4 Antibody (N-term) [AMR09866G].

Synonyms

Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway, ARTS, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Cerebral protein 7, Peanut-like protein 2, SEPT4, ARTS, PNUTL2, SEP4

Gene Name

HGNC:9165

Gene ID

5414

UniProt

O43236

Chromosomal Location

Cytoplasm {ECO:0000250|UniProtKB:P28661}. Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle Cell projection, axon {ECO:0000250|UniProtKB:P28661}. Cell projection, dendrite {ECO:0000250|UniProtKB:P28661}. Perikaryon {ECO:0000250|UniProtKB:P28661}. Note=In platelets, found in areas surrounding alpha-granules (PubMed:15116257) . Found in the sperm annulus, a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum (PubMed:25588830)

Applications

IHC-P, FC, WB

Dilution

WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Filament-forming cytoskeletal GTPase (Probable) . Plays an important role in male fertility and sperm motility (By similarity) . During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity) . Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity) .