APOE Antibody (C-term) [APR07063G]
Product Specifications
Background
Tissue Location: Produced by several tissues and cell types and mainly found associated with lipid particles in the plasma, the interstitial fluid and lymph (PubMed:25173806) . Mainly synthesized by liver hepatocytes (PubMed:25173806) . Significant quantities are also produced in brain, mainly by astrocytes and glial cells in the cerebral cortex, but also by neurons in frontal cortex and hippocampus (PubMed:3115992, PubMed:10027417) . It is also expressed by cells of the peripheral nervous system (PubMed:10027417, PubMed:25173806) . Also expressed by adrenal gland, testis, ovary, skin, kidney, spleen and adipose tissue and macrophages in various tissues (PubMed:25173806)
Synonyms
Apolipoprotein E, Apo-E, APOE
Gene Name
HGNC:613
Gene ID
348
UniProt
P02649
Chromosomal Location
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868, PubMed:8340399) . Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner (PubMed:9488694) . Lipidation induces the release from the extracellular matrix (PubMed:9488694) .
Applications
WB, IHC-P
Dilution
WB--1:2000 WB--1:1000 IHC-P--1:100~500
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
686069219118681475490868606922762297191186819179549395455147549082362051368606922762297939545568606921911868276229719179547768901893996112950167200303662063194875633120303980153061276359459395455948869423676495763594519118681917954939545523676495295161322762297295161322762297191795429516132939545514754908236205131475490823620513939545589399612517380628111074
Molecular Weight
36154
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality APOE Antibody (C-term) [APR07063G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=348
Uniprot URL
https://www.uniprot.org/uniprot/P02649
Available Sizes
Curated Selection
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