SPHK1 Antibody (Center) [APR06976G]

Product Specifications

Background

Tissue Location: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. Expressed in brain cortex (at protein level) (PubMed:29662056) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SPHK1 Antibody (Center) [APR06976G].

Synonyms

Sphingosine kinase 1, SK 1, SPK 1, SPHK1, SPHK, SPK

Gene Name

HGNC:11240

Gene ID

8877

UniProt

Q9NYA1

Chromosomal Location

Cytoplasm. Nucleus. Cell membrane. Endosome membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Cell junction, synapse {ECO:0000250|UniProtKB:Q8CI15}. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831) . Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359) . Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity) {ECO:0000250|UniProtKB:Q8CI15, ECO:0000269|PubMed:19854831, ECO:0000269|PubMed:24929359}

Applications

WB, IHC-P

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.