HMGCS2 Antibody (C-term) [APR07772G]
Product Specifications
Background
Tissue Location: Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas Very low expression in heart and skeletal muscle (PubMed:7893153, PubMed:21952825, PubMed:16940161) . Not detected in brain (PubMed:21952825) .
Synonyms
Hydroxymethylglutaryl-CoA synthase, mitochondrial, HMG-CoA synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, HMGCS2
Gene Name
HMGCS2
Gene ID
3158
UniProt
P54868
Chromosomal Location
Mitochondrion {ECO:0000250|UniProtKB:P22791}.
Applications
IHC-P, FC, WB
Dilution
WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
Molecular Weight
56635
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HMGCS2 Antibody (C-term) [APR07772G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3158
Uniprot URL
https://www.uniprot.org/uniprot/P54868
Available Sizes
Curated Selection
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