FOLR2 Antibody (N-term) [AMM04583G]

Product Specifications

Background

Tissue Location: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FOLR2 Antibody (N-term) [AMM04583G].

Synonyms

Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2

Gene Name

FOLR2

Gene ID

2350

UniProt

P14207

Chromosomal Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted

Applications

WB, IHC-P, FC

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.