TLE1 Antibody (N-term) [AMM08214G]
Product Specifications
Background
Tissue Location: In all tissues examined, mostly in brain, liver and muscle
Synonyms
Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1
Gene Name
TLE1
Gene ID
7088
UniProt
Q04724
Chromosomal Location
Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components
Applications
WB, IF
Dilution
IF--1:25 WB--1:1000
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF- 1- and HES1-mediated transcriptional repression (By similarity) . The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Molecular Weight
83201
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TLE1 Antibody (N-term) [AMM08214G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7088
Uniprot URL
https://www.uniprot.org/uniprot/Q04724
Available Sizes
Curated Selection
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