TLE1 Antibody (N-term) [AMM08214G]

Product Specifications

Background

Tissue Location: In all tissues examined, mostly in brain, liver and muscle

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TLE1 Antibody (N-term) [AMM08214G].

Synonyms

Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1

Gene Name

TLE1

Gene ID

7088

UniProt

Q04724

Chromosomal Location

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components

Applications

WB, IF

Dilution

IF--1:25 WB--1:1000

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF- 1- and HES1-mediated transcriptional repression (By similarity) . The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Molecular Weight

83201

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.