PAX6 Antibody (Center) [APR12741G]

Product Specifications

Background

Tissue Location: [Isoform 1]: Expressed in lymphoblasts.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PAX6 Antibody (Center) [APR12741G].

Synonyms

Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2

Gene Name

PAX6

Gene ID

5080

UniProt

P26367

Chromosomal Location

Nucleus {ECO:0000250|UniProtKB:P63015}. [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}

Applications

Dilution

WB--1:1000

Function

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity) . Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity) . Acts as a transcriptional repressor of NFATC1- mediated gene expression (By similarity) .

Molecular Weight

46683

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.