SFN Antibody (Center) [APR13281G]

Product Specifications

Background

Tissue Location: Present mainly in tissues enriched in stratified squamous keratinizing epithelium

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SFN Antibody (Center) [APR13281G].

Synonyms

14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1

Gene Name

SFN

Gene ID

2810

UniProt

P31947

Chromosomal Location

Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway

Applications

Dilution

WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.