STAT3 Antibody (C-term S727) [APR11199G]

Product Specifications

Background

Tissue Location: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4 (+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195)

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STAT3 Antibody (C-term S727) [APR11199G].

Synonyms

Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF

Gene Name

HGNC:11364

Gene ID

6774

UniProt

P40763

Chromosomal Location

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 Identified in a complex with LYN and PAG1

Applications

IF, WB

Dilution

WB--1:1000 IF--1:200

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.