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AubipyOMe

AubipyOMe serves as a potent inhibitor of tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme found in activated osteoclasts and macrophages, demonstrating IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b, while effectively inhibiting TRAP activity in extracts from murine macrophages and human lung tissue.

Product Specifications

CAS Number

1221591-26-9

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aubipyome.html

Purity

99.0

Smiles

[F-][P+5]([F-])([F-])([F-])([F-])[F-].[Cl-][Au+3]1([N]2=CC=C(C=C2C3=[N]1C=CC(OC)=C3)OC)[Cl-]

Molecular Formula

C12H12AuCl2F6N2O2P

Molecular Weight

629.07

References & Citations

[1]Molecular and functional properties of P2X receptorsrecent progress and persisting challenges|[2]Covalent binding of 3'-O- (4-benzoyl) benzoyl adenosine 5'-triphosphate (BzATP) to the isolated alpha and beta subunits and the alpha 3 beta 3 core complex of TF1|[3]P2X7 receptor inhibition increases CNTF in the subventricular zone, but not neurogenesis or neuroprotection after stroke in adult mice|[4]Osmotic surveillance mediates rapid wound closure through nucleotide release|[5]Benzophenone-ATP: A photoaffinity label for the active site of ATPasesTest1986|[6]Receptor-independent effects of 2 (3) -O- (4-benzoylbenzoyl) ATP triethylammonium salt on cytosolic p|[7]P2times 7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation|[8]Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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