CNTN1 Antibody (Center) [APR11618G]
Product Specifications
Background
Tissue Location: Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
Synonyms
Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1
Gene Name
CNTN1
Gene ID
1272
UniProt
Q12860
Chromosomal Location
[Isoform 1]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side
Applications
WB
Dilution
WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity) .
Molecular Weight
113320
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CNTN1 Antibody (Center) [APR11618G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1272
Uniprot URL
https://www.uniprot.org/uniprot/Q12860
Available Sizes
Curated Selection
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