RPGRIP1 Antibody (Center) [APR13147G]

Product Specifications

Background

Tissue Location: Strong expression in retina, with weaker expression in testis. Expressed in other neurons such as amacrine cells Colocalizes with RGPR in the outer segment of rod photoreceptors and cone outer segments.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RPGRIP1 Antibody (Center) [APR13147G].

Synonyms

X-linked retinitis pigmentosa GTPase regulator-interacting protein 1, RPGR-interacting protein 1, RPGRIP1

Gene Name

RPGRIP1

Gene ID

57096

UniProt

Q96KN7

Chromosomal Location

Cell projection, cilium. Note=Situated between the axonemal microtubules and the plasma membrane (By similarity) . In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity) . Colocalizes with RGPR in the photoreceptor connecting cilium (By similarity) . {ECO:0000250|UniProtKB:Q9EPQ2}

Applications

WB, IHC-P, FC

Dilution

WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.