SOCS1 Antibody (N-term) [AMM07926G]
Product Specifications
Background
Tissue Location: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes
Synonyms
Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, JAB, STAT-induced STAT inhibitor 1, SSI-1, Tec-interacting protein 3, TIP-3, SOCS1, SSI1, TIP3
Gene Name
SOCS1
Gene ID
8651
UniProt
O15524
Chromosomal Location
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3
Applications
WB, IHC-P, IF, FC
Dilution
WB--1:2000 WB--1:1000 IHC-P--1:100~500 IF--1:10~50 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) . Regulates interferon-gamma mediated sensory neuron survival (By similarity) . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Molecular Weight
23551
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SOCS1 Antibody (N-term) [AMM07926G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8651
Uniprot URL
https://www.uniprot.org/uniprot/O15524
Available Sizes
Curated Selection
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