PP1C gamma (PPP1CC) Antibody (N-term) [AMR09428G]

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PP1C gamma (PPP1CC) Antibody (N-term) [AMR09428G].

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center Note=Colocalizes with SPZ1 in the nucleus (By similarity) . Colocalizes with URI1 at mitochondrion (PubMed:17936702) . Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654) . Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019) . In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654) . Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430) . Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430) . Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430) . Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430) . Colocalizes with DYNLT4 in the microtubule organizing center (MTOC) (PubMed:23789093) {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:12529430, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:17965019, ECO:0000269|PubMed:23789093}

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.